6th NovAliX Conference

Biophysics in Drug Discovery 2019 | European Edition

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Cannes, France    March 20-22, 2019

Keynote Lecture

Integrative Structural Biology of GPCRs (KL01)

Prof. Kurt WÜTHRICH
Prof. Kurt WÜTHRICH
THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland
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Session 1: Hot Topics

Fragment Based Target Sreening to Prioritise Novel Antimicrobial Targets (OC05)

Dr Peter CANNING
Dr Peter CANNING
LIFEARC, Stevenage, United Kingdom
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Structure of an Essential Inner Membrane Protein-LPS Complex (OC04)

Dr Thomas CLAIRFEUILLE
Dr Thomas CLAIRFEUILLE
GENENTECH, INC., South San Francisco, United States
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High-Throughput, Automated Crystallography Pipelines for Drug Discovery (OC03)

Dr Irina CORNACIU
Dr Irina CORNACIU
EMBL GRENOBLE, Grenoble, France
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Biophysics as a Key Element in the Early Phase of Drug Discovery (IL01)

Dr Matthias FRECH
Dr Matthias FRECH
MERCK, Darmstadt, Germany
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Fragment Based Screening: Critical Aspects of its Performance and Evaluation Screening a Diverse Set of Cancer Target Classes (OC02)

Dr Andrea GOHLKE
Dr Andrea GOHLKE
BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom
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The Way Home: Molecular Recognition Path of L-TRP to IDO1 (OC01)

Prof. Antonio MACCHIARULO
Prof. Antonio MACCHIARULO
UNIVERSITY OF PERUGIA, Perugia, Italy
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Session 2: X-ray Crystallography − Cryo-EM Complementarity

Using X-ray and Cryo-EM Approaches to Study Allosteric Regulation of GTP Cyclohydrolase I (OC06)

Ms Rebecca EBENHOCH
Ms Rebecca EBENHOCH
BOEHRINGER INGELHEIM, Biberach, Germany
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Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development (IL03)

Prof. Karl-Peter HOPFNER
Prof. Karl-Peter HOPFNER
LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany
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High-Resolution Structure Determination of Dynamic Macromolecular Complexes by Cryo-EM (IL02)

Prof. Holger STARK
Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany
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Cryo-EM, a New Tool for Drug Discovery at Novartis (IL04)

Dr Christian WIESMANN
Dr Christian WIESMANN
NOVARTIS, Basel, Switzerland
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Session 3: Chemical Biology Meets Biophysics for Drug Discovery

Biophysical and Structural Principles of PROTAC Mechanism of Action (IL06)

Prof. Alessio CIULLI
Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom
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Rational Design of Kinase Inhibitors Using Structure and Biophysical Data (IL07)

Prof. Stefan KNAPP
Prof. Stefan KNAPP
GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany
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Illuminating the Path to New E3-Ligases for Targeted Protein Degradation (IL05)

Ms Hannah LITHGOW
Ms Hannah LITHGOW
UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom
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The Development and Biophysical Characterisation of Click-Tagged, Reversible Probes to Measure Target Occupancy of ERK1/2 Kinase Inhibitors (OC07)

Dr Chiara Rosa VALENZANO
Dr Chiara Rosa VALENZANO
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom
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The PROTAC Design Toolbox: Biophysically Enabling the Optimisation of a Potent SMARCA Degrader (OC08)

Dr David ZOLLMAN
Dr David ZOLLMAN
UNIVERSITY OF DUNDEE, Dundee, United Kingdom
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Session 4: MS-Based Methods

Identifying an Escape Route from Adverse Effects of the Liver X Receptor Ligands Using HDX-MS (OC09)

Dr Anna BELORUSOVA
Dr Anna BELORUSOVA
ASTRAZENECA, Molndal, Sweden
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Advances in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization (IL08)

Dr Sarah CIANFERANI
Dr Sarah CIANFERANI
UNIVERSITY OF STRASBOURG, Strasbourg, France
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Use of Mass Spectrometry in Small Molecule Lead Discovery (IL10)

Dr Jörg HOERNSCHEMEYER
Dr Jörg HOERNSCHEMEYER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Sugars in the Gas Phase? Novel Techniques to Unravel the Glycocode (IL09)

Prof. Kevin PAGEL
Prof. Kevin PAGEL
FREIE UNIVERSITÄT BERLIN, Berlin, Germany
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Session 5: Characterisation of Small Molecules Binding to RNA

Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule (IL12)

Prof. Frédéric ALLAIN
Prof. Frédéric ALLAIN
ETH ZURICH, Zurich, Switzerland
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Hit Discovery for Riboswitch Ligands (IL11)

Prof. Ruth BRENK
Prof. Ruth BRENK
UNIVERSITY OF BERGEN, Bergen, Norway
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Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation (OC10)

Dr Margaret BUTKO
Dr Margaret BUTKO
BIODESY, South San Francisco, United States
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Ribosomal Translation and Human Diseases (IL13)

Prof. Eric WESTHOF
Prof. Eric WESTHOF
INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France
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Session 6: Enabling Tools for Biophysical and Structural Studies

Impact of Mechanistic Enzymology and Bio-Structural Mass Spectrometry on the Progression of a Serine Hydrolase Inhibitor Discovery Project (OC12)

Dr Mathias ANTOINE
Dr Mathias ANTOINE
INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France
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Wave-Guided Interferometry and Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (IL18)

Dr Nicolas BOCQUET
Dr Nicolas BOCQUET
LEADXPRO AG, Villigen, Switzerland
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An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network (IL17)

Dr Patrick ENGLAND
Dr Patrick ENGLAND
INSTITUT PASTEUR, Paris, France
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New Biophysical Approaches to Study IRES RNA/Ribosomes Interactions (OC11)

Dr Eric ENNIFAR
Dr Eric ENNIFAR
CNRS, Strasbourg, France
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Strategies to Enable Challenging Biophysical and Structural Studies (IL15)

Dr Stefan GESCHWINDNER
Dr Stefan GESCHWINDNER
ASTRAZENECA, Mölndal, Sweden
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SPR-Based Approaches to Enable Direct Binding Assays for Membrane Proteins (IL16)

Dr Sylwia HUBER
Dr Sylwia HUBER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Innovating Drug Discovery by Locking GPCRs in Functional Conformations (IL14)

Dr Christel MENET
Dr Christel MENET
CONFO THERAPEUTICS, Brussels, Belgium
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