6th NovAliX Conference

Biophysics in Drug Discovery 2019 | European Edition

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Cannes, France    March 20-22, 2019

Keynote Speaker

Integrative Structural Biology of GPCRs

Prof. Kurt WÜTHRICH
Prof. Kurt WÜTHRICH
THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland
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Session 1: Hot Topics

Title of talk to be confirmed

Dr Matthias FRECH
Dr Matthias FRECH
MERCK, Darmstadt, Germany

Session 2: X-ray Crystallography − Cryo-EM Complementarity

Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development

Prof. Karl-Peter HOPFNER
Prof. Karl-Peter HOPFNER
LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany
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Combining Cryo-EM and X-ray for Structural Studies of Dynamic Macromolecular Complexes

Prof. Holger STARK
Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany
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Cryo-EM, a Tool for Drug Discovery at Novartis

Dr Christian WIESMANN
Dr Christian WIESMANN
NOVARTIS, Basel, Switzerland
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Session 3: Chemical Biology Meets Biophysics for Drug Discovery

Biophysical and Structural Principals of PROTAC Mode of Action

Prof. Alessio CIULLI
Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom
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Rational Design of Kinase Inhibitors Using Structure and Biophysical Data

Prof. Stefan KNAPP
Prof. Stefan KNAPP
GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany
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Protein Degradation in Drug Discovery

Ms Hannah LITHGOW
Ms Hannah LITHGOW
UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom
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Session 4: MS-Based Methods

Progresses in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization

Dr Sarah CIANFERANI
Dr Sarah CIANFERANI
UNIVERSITY OF STRASBOURG, Strasbourg, France
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Mass Spectrometric Characterization of Proteins for Use in Small Molecule Drug Screening

Dr Jörg HOERNSCHEMEYER
Dr Jörg HOERNSCHEMEYER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Sugars in the Gas Phase – Novel Techniques to Unravel the Glycocode

Prof. Kevin PAGEL
Prof. Kevin PAGEL
FREIE UNIVERSITÄT BERLIN, Berlin, Germany
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Session 5: Characterisation of Small Molecules Binding to RNA

Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule

Prof. Frédéric ALLAIN
Prof. Frédéric ALLAIN
ETH ZURICH, Zurich, Switzerland

Hit Discovery for Riboswitch Ligands

Prof. Ruth BRENK
Prof. Ruth BRENK
UNIVERSITY OF BERGEN, Bergen, Norway
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Ribosomal Translation and Human Diseases

Prof. Eric WESTHOF
Prof. Eric WESTHOF
INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France
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Session 6: Enabling Tools for Biophysical and Structural Studies

Gene-to-Structure Pipeline Enabling Structure-Based Drug Discovery on Membrane Protein Targets

Dr Nicolas BOCQUET
Dr Nicolas BOCQUET
LEADXPRO AG, Villigen, Switzerland
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An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network

Dr Patrick ENGLAND
Dr Patrick ENGLAND
INSTITUT PASTEUR, Paris, France
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Tactics for Successful Enablement and/or Acceleration of Structural and Biophysical Studies

Dr Stefan GESCHWINDNER
Dr Stefan GESCHWINDNER
ASTRAZENECA, Mölndal, Sweden
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SPR-Based Approaches for Membrane Proteins Binding Assays

Dr Sylwia HUBER
Dr Sylwia HUBER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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The Confobody Technology

Dr Christel MENET
Dr Christel MENET
CONFO THERAPEUTICS, Brussels, Belgium
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