2nd NovAliX Virtual Conference

Biophysics in Drug Discovery | US Edition 2021

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Virtual Event    March 9-12, 2021

Keynote Speakers

Dissecting Protein-Protein Interaction Networks (KL01)

Prof. Michelle ARKIN
Prof. Michelle ARKIN
UNIVERSITY OF CALIFORNIA, San Francisco, United States
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Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02)

Prof. Brent NANNENGA
Prof. Brent NANNENGA
ARIZONA STATE UNIVERSITY, Tempe, United States
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Session 1: Hot Topics - COVID-19

SARS-CoV-2 3CL protease: Structure-Based Virtual Screening, Crystallographic Fragment Screening and Assay Implementation to Identify Novel Starting Points for Inhibition (OC02)

Dr Alexander METZ
Dr Alexander METZ
IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland
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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01)

Dr Xue WANG
Dr Xue WANG
THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands
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Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01)

Dr Dirksen BUSSIERE
Dr Dirksen BUSSIERE
ELI LILLY, San Diego, United States
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Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03)

Dr Dzung NGUYEN
Dr Dzung NGUYEN
PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany
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Session 3: Integrative Structural Biology & Biophysics

Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06)

Dr Amy BONCELLA
Dr Amy BONCELLA
COLORADO SCHOOL OF MINES, Golden, United States
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Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling: Stuctural Proteomics and Precision Therapeutics (IL02)

Prof. Patrick GRIFFIN
Prof. Patrick GRIFFIN
THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States
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Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05)

Dr Troy JOHNSON
Dr Troy JOHNSON
UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States
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Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04)

Dr Ariele VIACAVA FOLLIS
Dr Ariele VIACAVA FOLLIS
EMD SERONO R&D INSTITUTE INC, Stow, United States
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Identification, Characterization and Conformational Assessment of STING Modulators (IL03)

Dr Daniel WYSS
Dr Daniel WYSS
MERCK, Kenilworth, United States
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Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference

Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06)

Dr Kenneth BORRELLI
Dr Kenneth BORRELLI
SCHRÖDINGER, INC., New York, United States
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Structural Characterization of Different TRPA1 Inhibitors (IL05)

Dr Lionel ROUGÉ
Dr Lionel ROUGÉ
GENENTECH, San Francisco, United States
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Using Cryo-EM for GPCR Drug Discovery and Development (IL07)

Prof. Patrick M. SEXTON
Prof. Patrick M. SEXTON
MONASH UNIVERSITY, Parkville, Australia
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From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04)

Dr Corey STRICKLAND
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
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Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.

Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10)

Ms Yuliya DUBIANOK
Ms Yuliya DUBIANOK
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08)

Dr Alessandra FEOLI
Dr Alessandra FEOLI
UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy
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Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09)

Dr Volker GATTERDAM
Dr Volker GATTERDAM
LINO BIOTECH AG, Zurich, Switzerland
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Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08)

Dr Reto HORST
Dr Reto HORST
PFIZER, INC., Grotton, United States
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SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09)

Prof. William POMERANTZ
Prof. William POMERANTZ
UNIVERSITY OF MINNESOTA, Minneapolis, United States
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Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07)

Prof. Terence STRICK
Prof. Terence STRICK
ECOLE NORMALE SUPERIEURE, Paris, France
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Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets

Speakers

Dr Benjamin APKER
Dr Benjamin APKER
MITEGEN, Ithaca, United States
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Dr Corey STRICKLAND
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
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Dr Denis ZEYER
Dr Denis ZEYER
NOVALIX, Illkirch, France
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