7th NovAliX Conference

Biophysics in Drug Discovery 2019 | Asian Edition

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Kyoto, Japan    November 13-15, 2019

Keynote Speakers

Structure-biophysics Driven PROTAC Design for Degrading Undruggable Cancer Targets (KL01)

Prof. Alessio CIULLI
Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom
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From Fragments to Pharmaceuticals (KL02)

Dr Harren JHOTI
Dr Harren JHOTI
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom
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Session 1: Recent Advances in FBDD

Enabling Drug Discovery with Crude Reaction Mixture Screening (IL03)

Dr Ben DAVIS
Dr Ben DAVIS
VERNALIS RESEARCH, Cambridge, United Kingdom
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PhABits – Shining New Light on Fragments Approaches for Assessing Targets Tractability (IL01)

Dr Mike HANN
Dr Mike HANN
GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom
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Ligand-Based Fluorine NMR Screening in Drug Discovery (IL02)

Dr Anna VULPETTI
Dr Anna VULPETTI
NOVARTIS, Basel, Switzerland
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Session 2: Challenging Targets (GPCRs, Ion Channels...)

Advancing Cryo-EM for Determination of G Protein-Coupled Receptor Structure (IL05)

Prof. Patrick M. SEXTON
Prof. Patrick M. SEXTON
MONASH UNIVERSITY, Parkville, Australia
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Structural Biology of Seven-Transmembrane Receptors Toward Drug Discovery (IL04)

Prof. Shigeyuki  YOKOYAMA
Prof. Shigeyuki YOKOYAMA
RIKEN, Yokohama City, Japan
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Session 3: Cryo-EM in Drug Discovery

Advancing Drug Discovery in Pharma Using Cryo-EM (IL06)

Dr Claudio CIFERRI
Dr Claudio CIFERRI
GENENTECH, South San Francisco, United States
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Session 4: X-ray Crystallography / Cryo-EM Complementarity

Increased Performance in High-Throughput Compound and Fragment Screening Campaigns by the Use of "Club Class" Data Collection (IL07)

Dr Gerard BRICOGNE
Dr Gerard BRICOGNE
GLOBAL PHASING LTD., Cambridge, United Kingdom
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Applying Hybrid Biophysical and Structural Methods to Study Allosteric Regulation of GTP Cyclohydrolase I - A Target for Treating Inflammatory and Neuropathic Pain (IL09)

Dr Herbert NAR
Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany
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Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase (IL08)

Prof. Holger STARK
Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany
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Session 5: Hot Topics

Re-energizing Small Molecule Drug Discovery by Centaur Chemist™ (IL10)

Dr Daisuke TANAKA
EXSCIENTIA, Osaka, Japan