2nd NovAliX Virtual Conference

Biophysics in Drug Discovery | US Edition 2021

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Virtual Event    March 9-12, 2021

Program

Indicated times are in EST time zone.



01:00 pm

Start of sessions

Opening
Opening
01:00 pm
Opening Address by Conference Chairman
Dr Jean-Paul RENAUD
URANIA THERAPEUTICS, Ostwald, France
01:10 pm

Start of sessions

Session 1: Hot Topic - COVID-19
Session 1: Hot Topic - COVID-19
01:10 pm
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01)
Dr Xue WANG
THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands
01:25 pm

Start of sessions

Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.
Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.
01:25 pm
Introduction by the Session Chair
01:35 pm
The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01)
Dr Dirksen BUSSIERE
ELI LILLY, San Diego, United States
02:05 pm
Exhibitor Short Presentation - NanoImaging Services
Leading the Revolution: CryoEM-Enabled Drug Discovery
02:15 pm
Designing of Individual Bet Selective Peptidic Inhibitors by Studying BET`S Multivalent Binding Behaviour (OC02)
Ms Ailefeila AIHEMAITI
UNIVERSITY OF OXFORD, Oxford, United Kingdom
02:30 pm
Exhibitor Short Presentation - Crelux, a WuXi AppTec company
02:40 pm
Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03)
Dr Dzung NGUYEN
PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany
02:55 pm
Dissecting Protein-Protein Interaction Networks (KL01)
Prof. Michelle ARKIN
UNIVERSITY OF CALIFORNIA, San Francisco, United States
03:40 pm

Start of sessions

Networking
Networking
03:40 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:00 pm

Start of sessions

Session 3: Integrative Structural Biology & Biophysics
Session 3: Integrative Structural Biology & Biophysics
01:00 pm
Introduction by the Session Chair
01:10 pm
Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling: Stuctural Proteomics and Precision Therapeutics (IL02)
Prof. Patrick GRIFFIN
THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States
01:40 pm
Identification, Characterization and Conformational Assessment of STING Modulators (IL03)
Dr Daniel WYSS
MERCK, Kenilworth, United States
02:10 pm
Exhibitor Short Presentation - NovAliX
02:20 pm
Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04)
Dr Ariele VIACAVA FOLLIS
EMD SERONO R&D INSTITUTE INC, Stow, United States
02:35 pm
Exhibitor Short Presentation - Wuxi Biortus Biosciences Co., Ltd.
Your Partner for Proteins and Structures
02:45 pm
Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05)
Dr Troy JOHNSON
UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States
03:00 pm
Exhibitor Short Presentation - Bruker
An Introduction to Bruker SPR Technology
03:10 pm
Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06)
Dr Amy BONCELLA
COLORADO SCHOOL OF MINES, Golden, United States
03:25 pm

Start of sessions

Networking
Networking
03:25 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:00 pm

Start of sessions

Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference
Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference
01:00 pm
Introduction of the day
Session Chair
Dr Jeffrey LENGYEL
THERMO FISHER SCIENTIFIC, New York, United States
01:15 pm
From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04)
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
01:45 pm
Structural Characterization of Different TRPA1 Inhibitors (IL05)
Dr Lionel ROUGÉ
GENENTECH, San Francisco, United States
02:15 pm
Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06)
Dr Kenneth BORRELLI
SCHRÖDINGER, INC., New York, United States
02:45 pm
Using Cryo-EM for GPCR Drug Discovery and Development (IL07)
Prof. Patrick M. SEXTON
MONASH UNIVERSITY, Parkville, Australia
03:15 pm
Break
03:20 pm

Start of sessions

Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
03:20 pm
Moderator
Dr Jeffrey LENGYEL
THERMO FISHER SCIENTIFIC, New York, United States
Speakers
Dr Benjamin APKER
MITEGEN, Ithaca, United States
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
Dr Denis ZEYER
NOVALIX, Illkirch, France
04:05 pm

Start of sessions

Networking
Networking
04:05 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:00 pm

Start of sessions

Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.
Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.
01:00 pm
Introduction by the Session Chair
01:10 pm
Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08)
Dr Reto HORST
PFIZER, INC., Grotton, United States
01:40 pm
SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09)
Prof. William POMERANTZ
UNIVERSITY OF MINNESOTA, Minneapolis, United States
02:10 pm
Exhibitor Short Presentation - Dynamic Biosensors
02:20 pm
Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07)
Prof. Terence STRICK
ECOLE NORMALE SUPERIEURE, Paris, France
02:35 pm
Exhibitor Short Presentation - MiTeGen
02:45 pm
Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08)
Dr Alessandra FEOLI
UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy
03:00 pm
Exhibitor Short Presentation - Biosensing Instruments
03:10 pm
Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09)
Dr Volker GATTERDAM
LINO BIOTECH AG, Zurich, Switzerland
03:25 pm
Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10)
Ms Yuliya DUBIANOK
UNIVERSITY OF OXFORD, Oxford, United Kingdom
03:40 pm
Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02)
Prof. Brent NANNENGA
ARIZONA STATE UNIVERSITY, Tempe, United States
04:25 pm
Closing Remarks
04:30 pm
End of the Conference