6th NovAliX Conference

Biophysics in Drug Discovery 2019 | European Edition

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Cannes, France    March 20-22, 2019

Scientific Programme


12:00

Registration

13:15

Welcome Address

Dr Jean-Paul RENAUD
NOVALIX & RIBOSTRUCT, Illkirch, France

Session 1: Hot Topics

Session Chair

Dr Chun-wa CHUNG
GLAXOSMITHKLINE, Stevenage, United Kingdom

13:30

The Way Home: Molecular Recognition Path of L-TRP to IDO1 (OC01)

Prof. Antonio MACCHIARULO
UNIVERSITY OF PERUGIA, Perugia, Italy

13:45

Fragment Based Screening: Critical Aspects of its Performance and Evaluation Screening a Diverse Set of Cancer Target Classes (OC02)

Dr Andrea GOHLKE
BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom

14:00

High-Throughput, Automated Crystallography Pipelines for Drug Discovery (OC03)

Dr Irina CORNACIU
EMBL GRENOBLE, Grenoble, France

14:15

Exhibitor Short Presentation: ForteBio
Integrated Solutions for Early Stage Biologics Discovery

14:25

Structure of an Essential Inner Membrane Protein-LPS Complex (OC04)

Dr Thomas CLAIRFEUILLE
GENENTECH, INC., South San Francisco, United States

14:40

Fragment Based Target Sreening to Prioritise Novel Antimicrobial Targets (OC05)

Dr Peter CANNING
LIFEARC, Stevenage, United Kingdom

14:55

Biophysics as a Key Element in the Early Phase of Drug Discovery (IL01)

Dr Matthias FRECH
MERCK, Darmstadt, Germany

15:25

Coffee Break & Exhibition

Session 2: X-ray Crystallography − Cryo-EM Complementarity

Session Chair

Dr Michael HENNIG
LEADXPRO, Villigen, Switzerland

15:55

High-Resolution Structure Determination of Dynamic Macromolecular Complexes by Cryo-EM (IL02)

Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany

16:25

Using X-ray and Cryo-EM Approaches to Study Allosteric Regulation of GTP Cyclohydrolase I (OC06)

Ms Rebecca EBENHOCH
BOEHRINGER INGELHEIM, Biberach, Germany

16:40

Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development (IL03)

Prof. Karl-Peter HOPFNER
LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany

17:10

Exhibitor Short Presentation: ThermoFisher Scientific
New Optical Modes to Improve Cryo-EM Throughput

17:20

Cryo-EM, a New Tool for Drug Discovery at Novartis (IL04)

Dr Christian WIESMANN
NOVARTIS, Basel, Switzerland

Keynote Lecture

Chair

Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany

17:50

Integrative Structural Biology of GPCRs (KL01)

Prof. Kurt WÜTHRICH
THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland

18:50

Welcome Reception

20:00

End of the Day

08:30

Registration

Session 3: Chemical Biology Meets Biophysics for Drug Discovery

Session Chair

Dr Sandra JACOB
NOVARTIS, Basel, Switzerland

09:00

Illuminating the Path to New E3-Ligases for Targeted Protein Degradation (IL05)

Ms Hannah LITHGOW
UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom

09:30

The Development and Biophysical Characterisation of Click-Tagged, Reversible Probes to Measure Target Occupancy of ERK1/2 Kinase Inhibitors (OC07)

Dr Chiara Rosa VALENZANO
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom

09:45

Biophysical and Structural Principles of PROTAC Mechanism of Action (IL06)

Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

10:15

Coffee Break & Exhibition

10:45

The PROTAC Design Toolbox: Biophysically Enabling the Optimisation of a Potent SMARCA Degrader (OC08)

Dr David ZOLLMAN
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

11:00

Exhibitor Short Presentation: Creoptix
Pushing Boundaries in Kinetics Analysis

11:10

Rational Design of Kinase Inhibitors Using Structure and Biophysical Data (IL07)

Prof. Stefan KNAPP
GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany

11:40

Poster Session

12:40

Lunch, Exhibition & Networking

Session 4: MS-Based Methods

Session Chair

Dr Stefan GESCHWINDNER
ASTRAZENECA, Mölndal, Sweden

14:00

Advances in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization (IL08)

Dr Sarah CIANFERANI
UNIVERSITY OF STRASBOURG, Strasbourg, France

14:30

Identifying an Escape Route from Adverse Effects of the Liver X Receptor Ligands Using HDX-MS (OC09)

Dr Anna BELORUSOVA
ASTRAZENECA, Molndal, Sweden

14:45

Sugars in the Gas Phase? Novel Techniques to Unravel the Glycocode (IL09)

Prof. Kevin PAGEL
FREIE UNIVERSITÄT BERLIN, Berlin, Germany

15:15

Exhibitor Short Presentation: Bruker Daltonics
High-Throughput SPR Screening in Drug Discovery

15:25

Use of Mass Spectrometry in Small Molecule Lead Discovery (IL10)

Dr Jörg HOERNSCHEMEYER
F. HOFFMANN-LA ROCHE, Basel, Switzerland

15:55

Coffee Break & Exhibition

Session 5: Characterisation of Small Molecules Binding to RNA

Session Chair

Dr Ursula EGNER
BAYER, Berlin, Germany

16:25

Hit Discovery for Riboswitch Ligands (IL11)

Prof. Ruth BRENK
UNIVERSITY OF BERGEN, Bergen, Norway

16:55

Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation (OC10)

Dr Margaret BUTKO
BIODESY, South San Francisco, United States

17:10

Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule (IL12)

Prof. Frédéric ALLAIN
ETH ZURICH, Zurich, Switzerland

17:40

Exhibitor Short Presentation: 2bind
Work with the Experts in Biophysics – A Quick Dive into 2bind’s Tailor-made Services for Drug Discovery

17:50

Ribosomal Translation and Human Diseases (IL13)

Prof. Eric WESTHOF
INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France

18:20

Poster Session & Drinks

19:20

End of the Day

20:00

Conference Dinner

Session 6: Enabling Tools for Biophysical and Structural Studies

Session Chair

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

09:00

Innovating Drug Discovery by Locking GPCRs in Functional Conformations (IL14)

Dr Christel MENET
CONFO THERAPEUTICS, Brussels, Belgium

09:30

New Biophysical Approaches to Study IRES RNA/Ribosomes Interactions (OC11)

Dr Eric ENNIFAR
CNRS, Strasbourg, France

09:45

Exhibitor Short Presentation: Synthelis
From Gene to Structure (FGTS)

09:55

Strategies to Enable Challenging Biophysical and Structural Studies (IL15)

Dr Stefan GESCHWINDNER
ASTRAZENECA, Mölndal, Sweden

10:25

Coffee Break & Exhibition

10:55

SPR-Based Approaches to Enable Direct Binding Assays for Membrane Proteins (IL16)

Dr Sylwia HUBER
F. HOFFMANN-LA ROCHE, Basel, Switzerland

11:25

Impact of Mechanistic Enzymology and Bio-Structural Mass Spectrometry on the Progression of a Serine Hydrolase Inhibitor Discovery Project (OC12)

Dr Mathias ANTOINE
INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France

11:40

An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network (IL17)

Dr Patrick ENGLAND
INSTITUT PASTEUR, Paris, France

12:10

Exhibitor Short Presentation: Crelux
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond

12:20

Wave-Guided Interferometry and Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (IL18)

Dr Nicolas BOCQUET
LEADXPRO AG, Villigen, Switzerland

12:50

Poster Prizes and Closing Remarks

13:00

Departure