2nd NovAliX Virtual Conference

Biophysics in Drug Discovery | US Edition 2021

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Virtual Event    March 9-12, 2021

Program

Indicated times are in EST time zone.

Start of the scientific sessions are:

  • 10:00 am (Pacific Standard Time) 
  • 01:00 pm (Eastern Standard Time)
  • 07:00 pm (Central European Time)
  • 03:00 am + 1 day (Japan Standard Time)




01:00 pm

Start of sessions

Opening
Opening
01:00 pm
Opening Address by Conference Chairman
Dr Jean-Paul RENAUD
URANIA THERAPEUTICS, Ostwald, France
01:10 pm

Start of sessions

Session 1: Hot Topic - COVID-19
Session 1: Hot Topic - COVID-19
01:10 pm
Introduction by the Session Chair
Dr Chaohong SUN
ABBVIE, North Chicago, United States
01:15 pm
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01)
Dr Xue WANG
THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands
01:30 pm
SARS-CoV-2 3CL protease: Structure-Based Virtual Screening, Crystallographic Fragment Screening and Assay Implementation to Identify Novel Starting Points for Inhibition (OC02)
Dr Alexander METZ
IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland
01:45 pm

Start of sessions

Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.
Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.
01:45 pm
Introduction by the Session Chair
Dr Matthias FRECH
MERCK, Darmstadt, Germany
01:50 pm
The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01)
Dr Dirksen BUSSIERE
ELI LILLY, San Diego, United States
02:20 pm
Exhibitor Short Presentation - NanoImaging Services
Leading the Revolution: CryoEM-Enabled Drug Discovery
Dr Melanie ADAMS-CIOABA
NANOIMAGING SERVICES, San Diego, United States
02:30 pm
Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03)
Dr Dzung NGUYEN
PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany
02:45 pm
Exhibitor Short Presentation - Crelux, a WuXi AppTec company
Target To Hit Solutions: Drug Discovery Of Bifunctional Molecules
Dr Thomas WALDMANN
CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany
02:55 pm
Dissecting Protein-Protein Interaction Networks (KL01)
Prof. Michelle ARKIN
UNIVERSITY OF CALIFORNIA, San Francisco, United States
03:40 pm

Start of sessions

Networking
Networking
03:40 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:00 pm

Start of sessions

Session 3: Integrative Structural Biology & Biophysics
Session 3: Integrative Structural Biology & Biophysics
01:00 pm
Introduction by the Session Chair
Dr MariJean EGGEN
ELI LILLY, Indianapolis, United States
01:05 pm
Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling: Stuctural Proteomics and Precision Therapeutics (IL02)
Prof. Patrick GRIFFIN
THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States
01:35 pm
Exhibitor Short Presentation - NovAliX
NovAliX: Drug Discovery fueled with Biophysics
Dr James TARVER
NOVALIX, Philadelphia, United States
01:45 pm
Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04)
Dr Ariele VIACAVA FOLLIS
EMD SERONO R&D INSTITUTE INC, Stow, United States
02:00 pm
Exhibitor Short Presentation - Wuxi Biortus Biosciences Co., Ltd.
Your Partner for Proteins and Structures
Dr Yujian YOU
WUXI BIORTUS BIOSCIENCES CO., LTD., Jiangyin, China
02:10 pm
Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05)
Dr Troy JOHNSON
UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States
02:25 pm
Exhibitor Short Presentation - Bruker
An Introduction to Bruker SPR Technology
Mr Cameron PARAST
BRUKER SCIENTIFIC, Billerica, United States
02:35 pm
Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06)
Dr Amy BONCELLA
COLORADO SCHOOL OF MINES, Golden, United States
02:50 pm
Identification, Characterization and Conformational Assessment of STING Modulators (IL03)
Dr Daniel WYSS
MERCK, Kenilworth, United States
03:20 pm

Start of sessions

Networking
Networking
03:20 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:15 pm

Start of sessions

Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference
Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference
Introduction by the Session Chair
Dr Jeffrey LENGYEL
THERMO FISHER SCIENTIFIC, New York, United States
01:15 pm
From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04)
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
01:45 pm
Structural Characterization of Different TRPA1 Inhibitors (IL05)
Dr Lionel ROUGÉ
GENENTECH, San Francisco, United States
02:15 pm
Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06)
Dr Kenneth BORRELLI
SCHRÖDINGER, INC., New York, United States
02:45 pm
Using Cryo-EM for GPCR Drug Discovery and Development (IL07)
Prof. Patrick M. SEXTON
MONASH UNIVERSITY, Parkville, Australia
03:15 pm
Break
03:20 pm

Start of sessions

Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
03:20 pm
Moderator
Dr Jeffrey LENGYEL
THERMO FISHER SCIENTIFIC, New York, United States
Speakers
Dr Benjamin APKER
MITEGEN, Ithaca, United States
Dr Corey STRICKLAND
MERCK, Kenilworth, United States
Dr Denis ZEYER
NOVALIX, Illkirch, France
04:05 pm

Start of sessions

Networking
Networking
04:05 pm
Networking, Exhibition & Posters
05:00 pm
End of the day
12:00 pm

Start of sessions

Networking
Networking
12:00 pm
Networking, Exhibition & Posters
01:00 pm

Start of sessions

Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.
Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.
01:00 pm
Introduction by the Session Chair
Dr Daniel WYSS
MERCK, Kenilworth, United States
01:05 pm
Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08)
Dr Reto HORST
PFIZER, INC., Grotton, United States
01:35 pm
Exhibitor Short Presentation - Dynamic Biosensors
heliX® biosensor – your structure-based drug discovery tool
Dr Joanna DEEK
DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany
01:45 pm
Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07)
Prof. Terence STRICK
ECOLE NORMALE SUPERIEURE, Paris, France
02:00 pm
Exhibitor Short Presentation - MiTeGen
Crystallography and Cryo-EM - Sample Preparation Technology Developments
Dr Benjamin APKER
MITEGEN, Ithaca, United States
02:10 pm
Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08)
Dr Alessandra FEOLI
UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy
02:25 pm
SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09)
Prof. William POMERANTZ
UNIVERSITY OF MINNESOTA, Minneapolis, United States
02:55 pm
Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09)
Dr Volker GATTERDAM
LINO BIOTECH AG, Zurich, Switzerland
03:10 pm
Exhibitor Short Presentation - Biosensing Instruments
Cell-based SPR Introduction
Mrs Akemi UEKI
BIOSENSING INSTRUMENT, Tempe, United States
03:20 pm
Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10)
Ms Yuliya DUBIANOK
UNIVERSITY OF OXFORD, Oxford, United Kingdom
03:35 pm
Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02)
Prof. Brent NANNENGA
ARIZONA STATE UNIVERSITY, Tempe, United States
04:20 pm
Closing Remarks
Dr Jean-Paul RENAUD
URANIA THERAPEUTICS, Ostwald, France
04:30 pm
End of the Conference