7th NovAliX Conference

Biophysics in Drug Discovery 2019 | Asian Edition

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Kyoto, Japan    November 13-15, 2019

Programme


13:00

Registration

13:45

Welcome Address

Session 1: Recent Advances in FBDD

Session Chair

Dr Mike HANN
GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom

14:00

PhABits – Shining New Light on Fragments Approaches for Assessing Targets Tractability (IL01)

Dr Mike HANN
GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom

14:30

Fast Molecular Interaction Screening and Affinity Determination in Biophysical Drug Discovery Projects with Dianthus NT.23 and Tycho NT.6 (OC01)

Mr Andreas LANGER
NANOTEMPER TECHNOLOGIES GMBH, Munich, Germany

14:45

Targeting TIR Domain Assemblies in TLR Signaling Pathways to Design Anti-Inflammatory Compounds (OC02)

Mr Md Habibur RAHAMAN
UNIVERSITY OF QUEENSLAND, Brisbane, Australia

15:00

Ligand-Based Fluorine NMR Screening in Drug Discovery (IL02)

Dr Anna VULPETTI
NOVARTIS, Basel, Switzerland

15:30

Coffee Break & Exhibition

16:05

Exhibitor Short Presentation: Crelux – A WuXi AppTec company
A Fragment-Based Approach to Leverage Challenging Targets: Human STING

16:15

19F NMR Screening Applied to Multiple Cancer Target (OC03)

Dr Kenneth CAMERON
CRUK BEATSON INSTITUTE, Glasgow, United Kingdom

16:30

Enabling Drug Discovery with Crude Reaction Mixture Screening (IL03)

Dr Ben DAVIS
VERNALIS RESEARCH, Cambridge, United Kingdom

Academia Keynote Lecture

Session Chair

17:00

Structure-biophysics Driven PROTAC Design for Degrading Undruggable Cancer Targets (KL01)

Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

18:00

Welcome Reception

19:30

End of the Day

09:00

Registration

Session 2: Challenging Targets (GPCRs, Ion Channels...)

Session Chair

Dr Junichi SAITO
KYOWA KIRIN CO., LTD., Shizuoka, Japan

09:30

Structural Biology of Seven-Transmembrane Receptors Toward Drug Discovery (IL04)

Prof. Shigeyuki YOKOYAMA
RIKEN, Yokohama City, Japan

10:00

Venturing into the Untapped: Discovery of Small-Molecule Drugs Targeting Messenger RNAs Using Biophysical and Computational Methods (OC04)

Dr Ella MORISHITA
VERITAS IN SILICO, Tokyo, Japan

10:15

Coffee Break & Exhibition

10:45

Cryo-EM Structures Capturing the Transport Cycle of the P4-ATPase Flippase (OC05)

Mr Masahiro HIRAIZUMI
MITSUBISHI TANABE PHARMA CORPORATION, Yokohama, Japan

11:00

Advancing Cryo-EM for Determination of G Protein-Coupled Receptor Structure (IL05)

Prof. Patrick M. SEXTON
MONASH UNIVERSITY, Parkville, Australia

11:30

Poster Session

12:30

Lunch Break, Exhibition & Networking

Session 3: Cryo-EM in Drug Discovery

Session Chair

Dr Midori KAMIMURA
TEIJIN PHARMA LIMITED, Tokyo, Japan

14:00

Cryo-EM Structural Studies of The Human TRPV4 Ion-Channel: Insights and Characterization of a Novel Open-Conformation (OC06)

Dr Simon HOLTON
BAYER, Berlin, Germany

14:15

Cryo-EM Application for Drug Discovery (OC07)

Dr Wen-ti LIU
NOVALIX, Illkirch, France

14:30

Advancing Drug Discovery in Pharma Using Cryo-EM (IL06)

Dr Claudio CIFERRI
GENENTECH, South San Francisco, United States

15:00

Exhibitor Short Presentation: Thermo Fisher Scientific
Cryo-EM Single Particle Analysis Productivity: the State of the Art

15:10

Coffee Break & Exhibition

Session 4: X-ray Crystallography / Cryo-EM Complementarity

Session Chair

Dr Denis ZEYER
NOVALIX, Illkirch, France

15:45

Increased Performance in High-Throughput Compound and Fragment Screening Campaigns by the Use of "Club Class" Data Collection (IL07)

Dr Gerard BRICOGNE
GLOBAL PHASING LTD., Cambridge, United Kingdom

16:15

Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase (IL08)

Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany

16:45

Applying Hybrid Biophysical and Structural Methods to Study Allosteric Regulation of GTP Cyclohydrolase I - A Target for Treating Inflammatory and Neuropathic Pain (IL09)

Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany

17:15

Posters & Drinks

18:30

End of the Day

20:00

Conference Dinner

08:30

Registration

Session 5: Hot Topics

Session Chair

Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany

09:00

Re-energizing Small Molecule Drug Discovery by Centaur Chemist™ (IL10)

Dr Daisuke TANAKA
EXSCIENTIA, Osaka, Japan

Industry Keynote Lecture

Session Chair

Dr Mike HANN
GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom

09:30

From Fragments to Pharmaceuticals (KL02)

Dr Harren JHOTI
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom

Session 5: Hot Topics (continued)

Session Chair

10:30

Coffee Break & Exhibition

11:00

Exhibitor Short Presentation: NanoTemper Technologies
Biophysical Tools for Measuring Binding Affinity, Protein Stability or Protein Quality with just a Tiny Amount of Sample

11:10

Exhibitor Short Presentation: NovAliX
Single Particle Cryo-EM a Cutting Edge Service for Drug Discovery

11:20

Uncovering a Ligand-Induced Twisted State of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance (OC08)

Mr Dzung NGUYEN
PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany

11:35

Structural Mechanisms of and Drug Discovery Targeting Substrate of Gamma-Secretase in Alzheimer's Disease (OC09)

Prof. Chunyu WANG
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States

11:50

Poster Prize and Closing Remarks

12:05

End of the Conference