3rd NovAliX Conference

VENUE CHANGE!
The NovAliX Conference will now take place at HILTON STRASBOURG - More info here.

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Read the Testimonials of the 2015 Conference attendees now!

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Accommodation - important notice

During the same week of June a session of the European Parliament will take place in Strasbourg, we therefore recommend you to book your accommodation well in advance!

Confirmed Speakers


Keynote Lectures

X-ray Crystallography: an Ever-Reemerging Technology (KN02)
Dr Gerard BRICOGNEDr Gerard BRICOGNE
(GLOBAL PHASING LTD., Cambridge, United Kingdom)

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The Discovery of ABL001, an Allosteric Inhibitor of BCR-ABL (KN01)
Dr Sandra JACOBDr Sandra JACOB
(NOVARTIS, Basel, Switzerland)

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Session 1: Emerging Technologies

A 5-Year Retrospective on Non-Covalent Mass Spectrometry Applied to Drug Discovery (OC01)
Dr Mathias ANTOINEDr Mathias ANTOINE
(INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France)

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Maldi Mass Spectrometry: From Imaging to Ultra-High-Throughput-Screening (Maldi-Uhts) (OC02)
Dr Jens FUCHSERDr Jens FUCHSER
(BRUKER DALTONICS, Bremen, Germany)

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Mass Spectrometry and its Role in Drug Discovery (PL01)
Prof. Carol  ROBINSON Prof. Carol ROBINSON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)

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Exploring GPCR and Membrane Protein Dynamics with Solution NMR and X-ray Free-Electron Lasers (PL02)
Prof. Gebhard F.X. SCHERTLERProf. Gebhard F.X. SCHERTLER
(PAUL SCHERRER INSTITUTE, Villigen, Switzerland)

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Session 2: Biophysics for Challenging Targets

New Strategy for Challenging Targets: Time Resolved Molecular Interaction Analysis on Living Cells Using LigandTracer (PL03)
Dr Karl  ANDERSSONDr Karl ANDERSSON
(RIDGEVIEW INSTRUMENTS AB, Vänge, Sweden)

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Thermodynamics of the Ribosome Translation Machinery (OC04)
Dr Eric ENNIFARDr Eric ENNIFAR
(CNRS, Strasbourg, France)

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Combining Binding Thermodynamics and Kinetic Binding Mechanisms to Assess The Selectivity of Inhibitors of Histone Deacetylase-Like Amidohydrolases (OC03)
Mr Christian MEYNERSMr Christian MEYNERS
(UNIVERSITY OF APPLIED SCIENCES DARMSTADT, Darmstadt, Germany)

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Probing the Structure and Dynamics of Proteins with Single-Molecule Spectroscopy (PL04)
Prof. Ben SCHULERProf. Ben SCHULER
(UNIVERSITY OF ZURICH, Zurich, Switzerland)

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Session 3: Special Focus on Cryo-EM

Cullin-Ring Ubiquitin E3 Ligase Regulation by the Cop9 Signalosome (OC05)
Dr Simone CAVADINIDr Simone CAVADINI
(FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland)

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High-Resolution Electron Cryo-Microscopy of Membrane Protein Complexes (PL05)
Prof. Werner KÜHLBRANDTProf. Werner KÜHLBRANDT
(MAX PLANCK INSTITUTE OF BIOPHYSICS, Frankfurt am Main, Germany)

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Visualizing Dynamic Macromolecular Complexes at High Resolution by Cryo-EM (PL06)
Prof. Holger STARKProf. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)

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EM in Industry: Expectations and Perspectives (PL07)
Dr Denis ZEYERDr Denis ZEYER
(NOVALIX, Illkirch, France)

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Session 4: Computational Biophysics

Structural Stability of Protein-Ligand Complexes: Applications in Virtual Screening (PL08)
Prof. Xavier BARRILProf. Xavier BARRIL
(BARCELONA UNIVERSITY, Barcelona, Spain)

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Uncoupling the Structure-Activity Relationships of Beta-2 Adrenergic Receptor Ligands from Membrane Binding (OC07)
Dr Callum DICKSONDr Callum DICKSON
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States)

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Diverse Applications of Free Energy Calculations in Drug Discovery (OC06)
Dr David RINALDODr David RINALDO
(SCHRÖDINGER, Mannheim, Germany)

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Computational Exploration of Protein Dynamics for Ligand Design (PL09)
Prof. Rebecca WADEProf. Rebecca WADE
(HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES AND HEIDELBERG UNIVERSITY, Heidelberg, Germany)

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Session 5: Cellular Biophysics

Insulin Degrading Enzyme: Drug Target Engagement in Hela Cells by Cellular Thermal Shift Assay (OC08)
Dr Adrien HERLEDANDr Adrien HERLEDAN
(INSTITUT PASTEUR DE LILLE, Lille, France)

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The Life and Death of Cells: Cellular Bioenergetics for Better Phenotype Based Drug Discovery (PL10)
Dr Magnus JANSSONDr Magnus JANSSON
(SYMCEL SVERIGE AB, Spanga, Sweden)

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Imaging of G-protein Coupled Receptors while Quantifying their Ligand-binding Free Energy Landscape to Mutiple Ligands (PL11)
Prof. Daniel MÜLLERProf. Daniel MÜLLER
(ETH ZÜRICH, Basel, Switzerland)

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Session 6: Biophysics for Biotherapeutics

The Neonatal Fc Receptor (FcRn) Binds Independently to Both Sites of the IgG Homodimer with Identical Affinities (PL12)
Dr Yasmina ABDICHEDr Yasmina ABDICHE
(RINAT-PFIZER, San Francisco, United States)

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Analysis of Bispecific Interactions with the Switchsense Biosensor (OC09)
Dr Ulrich RANTDr Ulrich RANT
(DYNAMIC BIOSENSORS GMBH, Martinsried/Planegg, Germany)

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Combinatorial SEC, AUC and TEM Approach for the Characterization of mAb Dimers (PL13)
Dr Arne RUFERDr Arne RUFER
(F. HOFFMANN-LA ROCHE LTD., Basel, Switzerland)

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Kinetic Excursion Analysis (Kinexa) of Avidity Enhancement of a Multi-Valent Adnectin Binding to Clustered Receptors on Cho Cells (OC10)
Dr Lumelle SCHNEEWEISDr Lumelle SCHNEEWEIS
(BRISTOL-MYERS SQUIBB, Princeton, NJ, United States)

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