| Tuesday June 9, 2015 |
| 11:00 | Registration |
|
| 13:30 | Welcome Address |
|
| SESSION 1: Method Development & Emerging Technologies |
|
| Session Chair |
Dr Johannes OTTL
(NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 13:45 | Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay |
Dr Pär NORDLUND
(KAROLINSKA INSTITUTE & NANYANG TECHNOLOGICAL UNIVERSITY, Singapore, Singapore) |
| 14:30 | No Crystal, No Problem: Hydrogen Deuterium Exchange Mass Spectrometry in Drug Discovery |
Dr Nino CAMPOBASSO
(GLAXOSMITHKLINE, Collegeville, United States) |
| 15:15 | Strategies to Target Protein-Protein Interactions |
Dr Marta WESTWOOD
(UCB, Slough, United Kingdom) |
| 15:40 | Coffe break & exhibition |
|
| 16:10 | Characterization of IL17A Inhibitors by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS) |
Mr Alfonso ESPADA
(ELI LILLY, ALCOBENDAS, Spain) |
| 16:35 | Second-Harmonic Generation (SHG) Measures and Resolves Protein Conformations: High-Throughput Structural Drug Discovery |
Dr Joshua SALAFSKY
(BIODESY, South San Francisco, United States) |
| KEYNOTE LECTURE |
|
| Chair |
Dr Ursula EGNER
(BAYER, Berlin, Germany) |
| 17:20 | Molecular Recognition in Protein-Ligand Complexes |
Prof. Gerhard KLEBE
(PHILIPPS-UNIVERSITY MARBURG, Marburg, Germany) |
| 18:20 | Welcome Reception |
|
| 19:35 | End of Day 1 |
|
| Wednesday June 10, 2015 |
| 08:30 | Registration |
|
| SESSION 2: Biophysics for Integral Membrane Proteins |
|
| Session Chair |
Dr Vincent MIKOL
(SANOFI, Vitry-sur-Seine, France) |
| 09:00 | Improving the Biophysical Properties of GPCRs for Drug Screening and Structural Biology |
Prof. Andreas PLÜCKTHUN
(UNIVERSITY OF ZÜRICH, Zurich, Switzerland) |
| 09:45 | Fluorine NMR Screening: Principles and Application to a Membrane Protein |
Dr Claudio DALVIT
(UNIVERSITY OF NEUCHÂTEL, Neuchâtel, Switzerland) |
| 10:30 | Coffee break & exhibition |
|
| 11:00 | Drug Discovery at the Single Molecule Level |
Dr Anders GUNNARSSON
(ASTRAZENECA, Mölndal, Sweden) |
| 11:25 | First Crystal Structure of Transmembrane Domain of G-Protein-Coupled Receptor MGLU5 Provides Insight Into Efficient New Drugs Design |
Dr Krzysztof OKRASA
(HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom) |
| SESSION 4 (anticipated): The Use of Kinetics in Drug Discovery |
|
| Session Chair |
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom) |
| 11:50 | Towards a Better Understanding of the Structural Mechanisms of Kinase Inhibitor Binding Kinetics |
Prof. Stefan KNAPP
(OXFORD UNIVERSITY, Oxford, United Kingdom) |
| 12:35 | Lunch, exhibition & networking |
|
| SESSION 3: Impact of Biophysics on Drug Discovery Projects |
|
| Session Chair |
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany) |
| 14:15 | Some Examples of Biophysics Helping Drug Discovery |
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom) |
| 15:00 | Making Every Interaction Count: Impact of Biophysical Methods Across the AstraZeneca Small-Molecule Portfolio |
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden) |
| 15:45 | Coffee break & exhibition |
|
| 16:15 | Biophysical Approaches for Hit Finding and Evaluation at Bayer |
Dr Ursula EGNER
(BAYER, Berlin, Germany) |
| 17:00 | Biophysics and Structural Biology Enabling the Discovery of Therapeutic Solutions: from Small Molecule Inhibitors to Vaccine Design |
Dr Vincent MIKOL
(SANOFI, Vitry-sur-Seine, France) |
| 17:45 | End of Day 2 |
|
| Thursday June 11, 2015 |
| SESSION 4: The Use of Kinetics in Drug Discovery |
|
| Session Chair |
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom) |
| 09:15 | CCR2 Antagonists: From Structure-Kinetics Relatiosnhips to in vivo Efficacy |
Prof. Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
| 10:00 | A Universal Homogeneous Assay for High-Throughput Determination of Binding Kinetics |
Dr Amaury FERNANDEZ MONTALVAN
(BAYER, Biberach an der Riss, Germany) |
| 10:25 | Coffee break & exhibition |
|
| 10:55 | CDK8 Inhibitors with Long Residence Time Emerging from a Retro-Design Approach: New Opportunities for Cancer Treatment |
Dr Anita WEGERT
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands) |
| 11:20 | Analysis of Binding Kinetics and Thermodynamics of DPP-4 Inhibitors and their Relationship to Structure |
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany) |
| 12:05 | Lunch, exhibition & networking |
|
| 13:45 | Poster Session |
|
| 16:00 | Coffe break & exhibition |
|
| 16:30 | Round Table Discussion
The Round Table will sum up the topics discussed in the first four Sessions of this Conference |
|
| Chair |
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom) |
| 17:15 | Poster Prizes |
|
| 17:25 | End of Day 3 |
|
| 20:00 | Conference Dinner at the Restaurant Maison Kammerzell
(optional, subject to prior booking) |
|
| Friday June 12, 2015 |
| SESSION 5: Special Focus on Epigenetics |
|
| Session Chair |
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
| 09:15 | Interrogating the Bromodomain Family Through Chemical Biology |
Dr Richard CUMMINGS
(CONSTELLATION PHARMACEUTICALS, Cambridge, United States) |
| 10:00 | When to get Biophysical with Readers, Writers and Erasers |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 10:45 | Coffee break & exhibition |
|
| 11:15 | Protein Methyltransferase Inhibitors as Personalised Cancer Therapeutics |
Dr Robert A. COPELAND
(EPIZYME, Cambridge, United States) |
| 12:00 | Closing Remarks |
|
| 12:15 | End of Day 4 |
|
| 14:15 | Guided tour of the Cathedral of Strasbourg
(subject to prior registration) |
|
