Biophysics in Drug Discovery 2018
Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs
Boston, USA June 13-15, 2018
Registration
Welcome Address
OC01 - Making Off-Rate Screening in FBDD More Amenable For Fast Dissociating Compounds
OC02 - Novel Active Site and Allosteric Site Binders Identified for FPPS Of T. cruzi
OC03 - Dynamic Single-Molecule Approaches to Accelerate the Development of More Efficient Drugs
OC04 - Quantitative Irreversible Tethering (QIT) for Covalent Ligand Discovery
OC05 - Large Protein Conformational Changes in Pi3kgamma Linked to the Binding of a New Class of Highly Selective Inhibitors
IL01 - Binding Kinetics and Thermodynamics in Drug Discovery
Coffee Break
Session Chair
IL02 - Chemical Probes for Epigenetic Targets
Exhibitor Short Presentation: Bruker
Development and Proof-of-Concept of a New Flow-through System for High Resolution NMR to Evaluate Biologics-producing Cell Lines and Their Growth Environments
Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics
OC06 - Quantification of Target Occupancy in Cells and Tumor Tissue Using FCCS
IL03 - How to Be Selectively Promiscuous
Session Chair
KL01 - From Simulations of Biomolecules to Fighting Diseases
Welcome Reception
End of the Day
Registration
IL04 - How Low Can You Go? Size and Resolution Limits Using Conventional Cryo-EM
IL05 - Cryo-EM for Characterization and Structure Based Drug Design
Coffee Break
OC07 - Cryo-EM to Address Intractable Targets in Drug Discovery
OC08 - Strength of Cryo-EM in Drug Discovery: One Could Always See Something
IL06 - Single Particle Cryo-EM Structure of the Insulin Receptor:Insulin Complex
Poster Session
Lunch & Networking
Session Chair
IL07 - New Tools Reveal Mechanisms of Allosteric Coupling in Human GPCRs
Exhibitor Short Presentation: Pall ForteBio
Dissecting Biomolecular Interactions - Pall ForteBio’s Next Gen SPR and BLI Label-Free Platforms: Providing Faster and Easier Solutions to Your Emerging Applications
OC09 - Enabling NMR-Based Fragment Screening Using Stabilized Native GPCR: Case Study of Adenosine Receptor
OC10 - Crystal Structures of Human Glycine Receptor Alpha3 Bound to a Novel Class of Analgesic Potentiators
IL08 - Structural Insight into Allosteric Modulation of GPCRs
Coffee Break
Session Chair
IL09 - Design Considerations for Synthetic Macrocycles in Drug Discovery
OC11 - Use of Complementary Biophysical Methods to Characterize Ligand Binding to IL-17A
OC12 - Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of α-Synuclein Aggregation in Parkinson’s Disease
IL10 - Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction
Posters & Drinks
End of the Day
Conference Dinner
Registration
Session Chair
IL11 - Attacking the Cancer Cell Surface-ome with Recombinant Antibodies
Exhibitor Short Presentation: Sierra Sensors
Controlling Throughput for SPR
IL12 - Multi-Specific Designer Proteins for Tumor Therapeutics
Coffee Break
Exhibitor Short Presentation: WuXi AppTec
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond.
IL13 - Emerging Higher Order Structure Techniques in Biotherapeutics Development
Poster Prizes and Closing Remarks
Farewell Lunch & Networking
End of the Conference