Biophysics in Drug Discovery 2017
Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs
Strasbourg, France June 6-9, 2017
Registration
Welcome Address
Session Chair
Use of Mini-G Proteins to Study the Activate State of G Protein-Coupled Receptors (PL01)
Biophysical Analysis to Aid and Complement Structure Based Drug Design for GPCRS (OC01)
Method for Rapid Optimization of Recombinant GPCR Protein Expression and Stability Using Virus-Like Particles (OC02)
Coffee Break
Enabling Biophysics on Membrane Proteins Targets : Example of a Human Nucleoside Transporter (PL02)
Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics
Exhibitor Short Presentation: Synthelis
Cell-free technology, expertise and services for your project in structural biology
Chair
Allosteric Mechanisms of Signal Transduction Investigated with Pentameric Ligand Gated Ion Channels: Consequences for Drug Design (KL01)
Welcome Reception
End of the Day
Registration
Session Chair
Study of Protein Folding and Ligand Binding by Pressure Jump NMR (PL03)
NMR as a Powerful Tool for Identifying Natural Compounds Able to Interfere with ELAV-mRNA Complexes (OC03)
Coffee Break
New NMR Tools for Drug Discovery : From Validation to Structure Determination (PL04)
Session Chair
Biophysical Assays to Answer Evolving Questions in Drug Discovery (OC04)
Exhibitor Short Presentation: Sierra Sensors
High-Throughput SPR Screening in Drug Discovery
Exhibitor Short Presentation: Biodesy
Screening with Structural Insight: High Throughput Measurement of Protein Conformational Change
Session Chair
Surface Plasmon Resonance Based Method to Discriminate Direct Competition and Allosteric Effects in Ternary Systems (OC10)
Lunch & Networking
Session Chair
FBLD and Biophysics: Better Together (KL02)
XCHEM: A High Throughput in Crystallo Fragment Screening Platform (OC06)
Fragment Screening against DC-SIGN Identifies Multiple Druggable Secondary Sites (OC07)
Coffee Break
Fragment Based Lead Generation – What Drives Success? (PL05)
A New Heuristic to Predict 3D Ligand Bound Conformation by Mining PDB Subpockets (OC08)
Exhibitor Short Presentation: Domainex
The MST Approach to Fragment Screening
Session Chair
Large Scale Protein Conformational Motions : From Fundamental Biophysics to Functional Dynamics (PL07)
Identifying Allosteric Modifiers of K-RAS Using Second Harmonic Generation (OC09)
Coffee Break
Analysis of Allosteric Modulators with Kinetic Fret (OC11)
Spectroscopic Adventures in Orthosteric and Allosteric Inhibition (PL08)
Session Chair
Precision of Biophysical Techniques that Determine Protein? Compound Dissociation Constants, Lessons from our Database of over 700 Ligand Kds Determined by ITC, FTSA(DSF), SPR, and SFA (OC05)
Lunch & Networking
Poster Session
Session Chair
Mechanistic Insights into TSPO and IDPs through NMR (PL09)
Increasing Success in Science by Increasing Diversity: From Methods to Gender
Session Chair
Finding Small-Molecules Inhibitors of the Interaction between the Intrinsically Disordered Androgen Receptor N-Terminal Domain and its Globular Partner RAP74 C-Terminal Domain (OC12)
Coffee Break
Systematic Development of Small Molecules Against Aβ Aggregation (PL10)
Poster Prizes
End of the Day
Conference Dinner
Cutting-Edge Mass Spectrometry Methods for the Multi-Level Structural Characterization of mAbs and ADCs (KL03)
Adnectin Bioconjugates for PET Imaging and Targeted Drug Conjugates (PL11)
Coffee Break
Exhibitor Short Presentation: Pall ForteBio
Our Label-Free, Real-Time Kinetics Technologies with Microplate Sampling Allow for High-Throughput in Screening & Characterisation of Drug Candidates Including Challenging Matrixes Like Crude Biologicals or Fragments in DMSO
Thermal Stabilization and Conformational Trapping of Membrane Transporters by in Vitro Selected Synthetic Nanobodies (PL12)
Closing Remarks and Departure