Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs
BφDD 2015
Strasbourg, France June 9-12, 2015
Registration
Welcome Address
Session Chair
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
No Crystal, No Problem: Hydrogen Deuterium Exchange Mass Spectrometry in Drug Discovery
Coffe break & exhibition
Characterization of IL17A Inhibitors by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)
Second-Harmonic Generation (SHG) Measures and Resolves Protein Conformations: High-Throughput Structural Drug Discovery
Molecular Recognition in Protein-Ligand Complexes
Welcome Reception
End of Day 1
Registration
Improving the Biophysical Properties of GPCRs for Drug Screening and Structural Biology
Fluorine NMR Screening: Principles and Application to a Membrane Protein
Coffee break & exhibition
First Crystal Structure of Transmembrane Domain of G-Protein-Coupled Receptor MGLU5 Provides Insight Into Efficient New Drugs Design
Session Chair
Towards a Better Understanding of the Structural Mechanisms of Kinase Inhibitor Binding Kinetics
Lunch, exhibition & networking
Some Examples of Biophysics Helping Drug Discovery
Making Every Interaction Count: Impact of Biophysical Methods Across the AstraZeneca Small-Molecule Portfolio
Coffee break & exhibition
Biophysical Approaches for Hit Finding and Evaluation at Bayer
Biophysics and Structural Biology Enabling the Discovery of Therapeutic Solutions: from Small Molecule Inhibitors to Vaccine Design
End of Day 2
Session Chair
CCR2 Antagonists: From Structure-Kinetics Relatiosnhips to in vivo Efficacy
A Universal Homogeneous Assay for High-Throughput Determination of Binding Kinetics
Coffee break & exhibition
CDK8 Inhibitors with Long Residence Time Emerging from a Retro-Design Approach: New Opportunities for Cancer Treatment
Analysis of Binding Kinetics and Thermodynamics of DPP-4 Inhibitors and their Relationship to Structure
Lunch, exhibition & networking
Poster Session
Coffe break & exhibition
Round Table Discussion
The Round Table will sum up the topics discussed in the first four Sessions of this Conference
Poster Prizes
End of Day 3
Conference Dinner at the Restaurant Maison Kammerzell
(optional, subject to prior booking)
Session Chair
Interrogating the Bromodomain Family Through Chemical Biology
When to get Biophysical with Readers, Writers and Erasers
Coffee break & exhibition
Protein Methyltransferase Inhibitors as Personalised Cancer Therapeutics
Closing Remarks
End of Day 4
Guided tour of the Cathedral of Strasbourg
(subject to prior registration)